The Malpetti Lab, led by Dr. Maura Malpetti, at the University of Cambridge focuses on in vivo biomarkers for inflammation, proteinopathies, and synaptic loss to investigate the pathophysiology of frontotemporal dementia and related disorders. To this end, we integrate PET imaging and clinical data with fluid markers and post-mortem pathology to identify and validate early diagnostic and prognostic markers that can inform the design of new disease-modifying treatment strategies. Supported by the Kissick Family Foundation, our Open Network for Frontotemporal dementia Inflammation Research (ON-FIRE) study aims to characterise targetable inflammatory pathways and related blood-based signatures in people with sporadic frontotemporal dementia across diverse communities and >20 research/healthcare centres.